{"text_format":"3","workbook":"xls","n_sheets":7,"sheets":["User Interface","Multi-Ligand Calc","KSHBG-X","KAlb-X","KCBG-X","Vermeulen Calc","Steroids 2009"],"not_rendered":{"charts":2,"external_links":1,"defined_names":8},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"User Interface","index":0,"n_rows":36,"n_cols":3,"rows_kept":36,"flags":["formulas_cached_only"]}
["Multi-Ligand Binding Model: T, DHT, E2, E1, C (with CBG calc)"]
["Solved by Successive Substitution (20 iterations)"]
["Spreadsheet Programmed by Norman Mazer, M.D., Ph.D."]
[]
["Date:","2009-01-24"]
[]
[]
["Subj ID:"]
["Subj Init:","YM"]
[]
["Input Data:"]
["T_tot (ng/dL)",600,"default 0"]
["DHT_tot (ng/dL)",50,"default 0"]
["E2_tot (pg/mL)",{"v":21.5,"d":"22"},"default 0"]
["E1_tot (pg/mL)",30,"default 0"]
["Cortisol (ug/dL)",13,"default 0"]
["Alb_tot (g/dL)",4.5,"default 4.3 *"]
["SHBG_tot (nmol/L)",30,"default 0"]
["CBG (mg/dL)",4,"default 0"]
[]
["Output:"]
["cFT (pg/mL)",{"v":131.50498042122652,"d":"131.50"}]
["cFDHT (pg/mL)",{"v":5.219074590875766,"d":"5.22"}]
["cFE2 (pg/mL)",{"v":0.5318827594138331,"d":"0.53"}]
["cFE1(pg/mL)",{"v":1.1394554219890158,"d":"1.14"}]
["cFC (ng/mL)",{"v":4.9626340275615455,"d":"4.96"}]
[]
["cBT (ng/dL)",{"v":321.8844132687252,"d":"321.88"}]
["cBDHT (ng/dL)",{"v":22.184742656916942,"d":"22.18"}]
["cBE2 (pg/mL)",{"v":16.299323848517552,"d":"16.30"}]
["cBE1 (pg/mL)",{"v":27.890422003636928,"d":"27.89"}]
[]
["Vermeulen Model (JCEM 1999;84:3666-3672):"]
["cFT (pg/mL)",{"v":133.3555132530329,"d":"133.36"}]
[]
["* If Alb is left empty, the default value will be 4.3 g/dL"]

{"sheet":"Multi-Ligand Calc","index":1,"n_rows":126,"n_cols":22,"rows_kept":126,"flags":["formulas_cached_only"]}
["Multi-Ligand Binding Model: T, DHT, E2, E1, C (with CBG calc)"]
["Solved by Successive Substitution (20 iterations)"]
["Spreadsheet Programmed by Norman Mazer, M.D., Ph.D."]
[]
["Parameter Values:"]
["MW_T",288.4]
["MW_ALB",69000]
["MW_E2",272.4]
["MW_E1",270.4]
["MW_DHT",290.4]
["MW_Cortisol (C)",{"v":362.46,"d":"362.5"}]
["MW_CBG",52000]
[]
["K_SHBG-T (L/nmol)",{"v":1,"d":"1.00E+00"}]
[]
["K_SHBG-E2 (L/nmol)",{"v":0.4950561655915015,"d":"4.95E-01"}]
[]
["K_SHBG-E1 (L/nmol)",{"v":0.09375,"d":"9.38E-02"}]
[]
["K_SHBG-DHT (L/nmol)",{"v":2.686122078647205,"d":"2.69E+00"}]
[]
["K_SHBG-C (L/nmol)",{"v":0.001,"d":"1.00E-03"}]
[]
["K_ALB-T (L/mol)",{"v":36000,"d":"3.60E+04"}]
[]
["K_ALB-E2 (L/mol)",{"v":45457.51231527094,"d":"4.55E+04"}]
[]
["K_ALB-E1 (L/mol)",{"v":36000,"d":"3.60E+04"}]
[]
["K_ALB-DHT (L/mol)",{"v":63647.61774956677,"d":"6.36E+04"}]
[]
["K_ALB-C (L/mol)",{"v":2700,"d":"2.70E+03"}]
[]
["K_CBG-C (L/mol)",{"v":52266666.666666664,"d":"5.23E+07"}]
[]
["K_CBG-T (L/mol)",{"v":3131415.2046783622,"d":"3.13E+06"}]
[]
["K_CBG-E2 (L/mol)",{"v":5749.333333333333,"d":"5.75E+03"}]
[]
["K_CBG-E1 (L/mol)",{"v":494.4426666666666,"d":"4.94E+02"}]
[]
["K_CBG-DHT (L/mol)",{"v":570807.0175438597,"d":"5.71E+05"}]
[]
["Iterations",0,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20]
[]
["T_tot (nmol/L)",null,{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"},{"v":20.804438280166437,"d":"20.80"}]
["FT (nmol/L)",null,{"v":0.36571489083022074,"d":"0.3657"},{"v":0.4390151270258269,"d":"0.4390"},{"v":0.452322581700867,"d":"0.4523"},{"v":0.4550237131828616,"d":"0.4550"},{"v":0.45568562752069314,"d":"0.4557"},{"v":0.4558802694037092,"d":"0.4559"},{"v":0.45594497730942163,"d":"0.4559"},{"v":0.4559679149514858,"d":"0.4560"},{"v":0.4559762859429546,"d":"0.4560"},{"v":0.45597937874712996,"d":"0.4560"},{"v":0.4559805272244032,"d":"0.4560"},{"v":0.45598095457175664,"d":"0.4560"},{"v":0.4559811137183456,"d":"0.4560"},{"v":0.4559811730050375,"d":"0.4560"},{"v":0.4559811950939652,"d":"0.4560"},{"v":0.45598120332425396,"d":"0.4560"},{"v":0.4559812063909076,"d":"0.4560"},{"v":0.45598120753357035,"d":"0.4560"},{"v":0.45598120795933816,"d":"0.4560"},{"v":0.4559812081179838,"d":"0.4560"}]
["% FT",null,{"v":1.7578695752572608,"d":"1.76"},{"v":2.1101993772374747,"d":"2.11"},{"v":2.174163876042167,"d":"2.17"},{"v":2.1871473146989544,"d":"2.19"},{"v":2.190328916282798,"d":"2.19"},{"v":2.1912644949338285,"d":"2.19"},{"v":2.1915755242672867,"d":"2.19"},{"v":2.1916857778668084,"d":"2.19"},{"v":2.191726014432468,"d":"2.19"},{"v":2.1917408805112046,"d":"2.19"},{"v":2.1917464008586314,"d":"2.19"},{"v":2.19174845497491,"d":"2.19"},{"v":2.1917492199395143,"d":"2.19"},{"v":2.1917495049108804,"d":"2.19"},{"v":2.1917496110849926,"d":"2.19"},{"v":2.191749650645247,"d":"2.19"},{"v":2.191749665385629,"d":"2.19"},{"v":2.191749670878028,"d":"2.19"},{"v":2.191749672924552,"d":"2.19"},{"v":2.1917496736871085,"d":"2.19"}]
["FT (pmol/L)",null,{"v":365.7148908302207,"d":"365.71"},{"v":439.0151270258269,"d":"439.02"},{"v":452.322581700867,"d":"452.32"},{"v":455.0237131828616,"d":"455.02"},{"v":455.6856275206931,"d":"455.69"},{"v":455.8802694037092,"d":"455.88"},{"v":455.94497730942163,"d":"455.94"},{"v":455.9679149514858,"d":"455.97"},{"v":455.9762859429546,"d":"455.98"},{"v":455.97937874712994,"d":"455.98"},{"v":455.9805272244032,"d":"455.98"},{"v":455.9809545717566,"d":"455.98"},{"v":455.9811137183456,"d":"455.98"},{"v":455.9811730050375,"d":"455.98"},{"v":455.9811950939652,"d":"455.98"},{"v":455.98120332425395,"d":"455.98"},{"v":455.98120639090763,"d":"455.98"},{"v":455.98120753357034,"d":"455.98"},{"v":455.9812079593382,"d":"455.98"},{"v":455.98120811798384,"d":"455.98"}]
["FT (pg/mL)",null,{"v":105.47217451543565,"d":"105.47"},{"v":126.61196263424847,"d":"126.61"},{"v":130.44983256253002,"d":"130.45"},{"v":131.22883888193726,"d":"131.23"},{"v":131.4197349769679,"d":"131.42"},{"v":131.47586969602972,"d":"131.48"},{"v":131.49453145603718,"d":"131.49"},{"v":131.5011466720085,"d":"131.50"},{"v":131.5035608659481,"d":"131.50"},{"v":131.50445283067228,"d":"131.50"},{"v":131.50478405151787,"d":"131.50"},{"v":131.5049072984946,"d":"131.50"},{"v":131.50495319637085,"d":"131.50"},{"v":131.5049702946528,"d":"131.50"},{"v":131.50497666509955,"d":"131.50"},{"v":131.50497903871482,"d":"131.50"},{"v":131.50497992313774,"d":"131.50"},{"v":131.5049802526817,"d":"131.50"},{"v":131.5049803754731,"d":"131.50"},{"v":131.50498042122652,"d":"131.50"}]
["BT (nmol/L)",null,{"v":8.952064501626708,"d":"8.95"},{"v":10.745947503020599,"d":"10.75"},{"v":11.07155379929214,"d":"11.07"},{"v":11.137627587852421,"d":"11.14"},{"v":11.153814377989981,"d":"11.15"},{"v":11.15857319629773,"d":"11.16"},{"v":11.160155046264762,"d":"11.16"},{"v":11.160715746483982,"d":"11.16"},{"v":11.160920366280914,"d":"11.16"},{"v":11.16099596571473,"d":"11.16"},{"v":11.161024038573894,"d":"11.16"},{"v":11.161034484441176,"d":"11.16"},{"v":11.161038374538942,"d":"11.16"},{"v":11.161039823712096,"d":"11.16"},{"v":11.161040363642325,"d":"11.16"},{"v":11.161040564819208,"d":"11.16"},{"v":11.161040639778884,"d":"11.16"},{"v":11.161040667709534,"d":"11.16"},{"v":11.161040678116779,"d":"11.16"},{"v":11.161040681994633,"d":"11.16"}]
["% BT",null,{"v":43.02959003781904,"d":"43.03"},{"v":51.652187664519005,"d":"51.65"},{"v":53.217268595264215,"d":"53.22"},{"v":53.5348632722773,"d":"53.53"},{"v":53.61266777687184,"d":"53.61"},{"v":53.63554183020442,"d":"53.64"},{"v":53.643145255712625,"d":"53.64"},{"v":53.645840354766335,"d":"53.65"},{"v":53.64682389392359,"d":"53.65"},{"v":53.64718727520212,"d":"53.65"},{"v":53.647322212078514,"d":"53.65"},{"v":53.64737242188059,"d":"53.65"},{"v":53.64739112028384,"d":"53.65"},{"v":53.64739808597614,"d":"53.65"},{"v":53.647400681240775,"d":"53.65"},{"v":53.647401648230996,"d":"53.65"},{"v":53.64740200853717,"d":"53.65"},{"v":53.64740214279048,"d":"53.65"},{"v":53.647402192814646,"d":"53.65"},{"v":53.64740221145419,"d":"53.65"}]
["BT (ng/dL)",null,{"v":258.17754022691423,"d":"258.18"},{"v":309.9131259871141,"d":"309.91"},{"v":319.3036115715853,"d":"319.30"},{"v":321.2091796336638,"d":"321.21"},{"v":321.67600666123104,"d":"321.68"},{"v":321.81325098122653,"d":"321.81"},{"v":321.8588715342757,"d":"321.86"},{"v":321.875042128598,"d":"321.88"},{"v":321.8809433635415,"d":"321.88"},{"v":321.88312365121277,"d":"321.88"},{"v":321.8839332724711,"d":"321.88"},{"v":321.8842345312835,"d":"321.88"},{"v":321.8843467217031,"d":"321.88"},{"v":321.8843885158568,"d":"321.88"},{"v":321.88440408744464,"d":"321.88"},{"v":321.8844098893859,"d":"321.88"},{"v":321.88441205122297,"d":"321.88"},{"v":321.8844128567429,"d":"321.88"},{"v":321.8844131568879,"d":"321.88"},{"v":321.8844132687252,"d":"321.88"}]
["SHBG-T (nmol/L)",null,{"v":10.971446724906622,"d":"10.97"},{"v":9.322663831247958,"d":"9.32"},{"v":9.056507955460297,"d":"9.06"},{"v":9.013313026167095,"d":"9.01"},{"v":9.005770973870796,"d":"9.01"},{"v":9.004254302909176,"d":"9.00"},{"v":9.00388418679399,"d":"9.00"},{"v":9.003775620594551,"d":"9.00"},{"v":9.003739576150826,"d":"9.00"},{"v":9.00372680704499,"d":"9.00"},{"v":9.003722148258912,"d":"9.00"},{"v":9.00372042718182,"d":"9.00"},{"v":9.003719788108357,"d":"9.00"},{"v":9.003719550314019,"d":"9.00"},{"v":9.0037194617587,"d":"9.00"},{"v":9.003719428769386,"d":"9.00"},{"v":9.003719416478305,"d":"9.00"},{"v":9.003719411898674,"d":"9.00"},{"v":9.003719410192277,"d":"9.00"},{"v":9.003719409556458,"d":"9.00"}]
["% SHBG-T",null,{"v":52.73608725771783,"d":"52.74"},{"v":44.81093748219851,"d":"44.81"},{"v":43.53161490591249,"d":"43.53"},{"v":43.32399127910983,"d":"43.32"},{"v":43.287739147738954,"d":"43.29"},{"v":43.28044901598344,"d":"43.28"},{"v":43.27866999118977,"d":"43.28"},{"v":43.2781481496578,"d":"43.28"},{"v":43.27797489603164,"d":"43.28"},{"v":43.27791351919625,"d":"43.28"},{"v":43.2778911259645,"d":"43.28"},{"v":43.27788285332061,"d":"43.28"},{"v":43.2778797815075,"d":"43.28"},{"v":43.27787863850938,"d":"43.28"},{"v":43.27787821285349,"d":"43.28"},{"v":43.27787805428485,"d":"43.28"},{"v":43.27787799520571,"d":"43.28"},{"v":43.27787797319296,"d":"43.28"},{"v":43.27787796499088,"d":"43.28"},{"v":43.277877961934706,"d":"43.28"}]
["CBG-T (nmol/L)",null,{"v":0.8809270536331082,"d":"0.88"},{"v":0.7358269458978793,"d":"0.74"},{"v":0.6763765254139998,"d":"0.68"},{"v":0.653497666146924,"d":"0.65"},{"v":0.6448529283056603,"d":"0.64"},{"v":0.6416107809595285,"d":"0.64"},{"v":0.6403990471076835,"d":"0.64"},{"v":0.6399469130879035,"d":"0.64"},{"v":0.6397783377346957,"d":"0.64"},{"v":0.6397155074067221,"d":"0.64"},{"v":0.6396920933336291,"d":"0.64"},{"v":0.6396833685434413,"d":"0.64"},{"v":0.6396801175191363,"d":"0.64"},{"v":0.639678906140323,"d":"0.64"},{"v":0.6396784547654107,"d":"0.64"},{"v":0.6396782865778433,"d":"0.64"},{"v":0.6396782239092488,"d":"0.64"},{"v":0.639678200558229,"d":"0.64"},{"v":0.6396781918573791,"d":"0.64"},{"v":0.6396781886153458,"d":"0.64"}]
["% CBG-T",null,{"v":4.234322704463139,"d":"4.23"},{"v":3.536874853282473,"d":"3.54"},{"v":3.2511164988232926,"d":"3.25"},{"v":3.141145448612881,"d":"3.14"},{"v":3.0995930753892074,"d":"3.10"},{"v":3.0840091538121333,"d":"3.08"},{"v":3.0781847530975988,"d":"3.08"},{"v":3.076011495575856,"d":"3.08"},{"v":3.0752012100447703,"d":"3.08"},{"v":3.0748992056016444,"d":"3.07"},{"v":3.0747866619569773,"d":"3.07"},{"v":3.0747447247988076,"d":"3.07"},{"v":3.0747290982086484,"d":"3.07"},{"v":3.0747232755144855,"d":"3.07"},{"v":3.0747211059057404,"d":"3.07"},{"v":3.0747202974841668,"d":"3.07"},{"v":3.0747199962571226,"d":"3.07"},{"v":3.0747198840165537,"d":"3.07"},{"v":3.074719842194469,"d":"3.07"},{"v":3.074719826611095,"d":"3.07"}]
["E2_tot (pmol/L)",null,{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"},{"v":78.92804698972101,"d":"78.93"}]
["FE2 (pmol/L)",null,{"v":1.7345942410602926,"d":"1.73"},{"v":1.9175487329474743,"d":"1.92"},{"v":1.9459751620791153,"d":"1.95"},{"v":1.9510771351775678,"d":"1.95"},{"v":1.9521637811507666,"d":"1.95"},{"v":1.952446451634326,"d":"1.95"},{"v":1.9525334090469533,"d":"1.95"},{"v":1.9525630515605052,"d":"1.95"},{"v":1.952573682791265,"d":"1.95"},{"v":1.95257758207816,"d":"1.95"},{"v":1.952579025710099,"d":"1.95"},{"v":1.9525795622346949,"d":"1.95"},{"v":1.9525797619422243,"d":"1.95"},{"v":1.9525798363244888,"d":"1.95"},{"v":1.9525798640355256,"d":"1.95"},{"v":1.9525798743602758,"d":"1.95"},{"v":1.9525798782072905,"d":"1.95"},{"v":1.9525798796407154,"d":"1.95"},{"v":1.952579880174823,"d":"1.95"},{"v":1.9525798803738368,"d":"1.95"}]
["% FE2",null,{"v":2.197690564022435,"d":"2.20"},{"v":2.429489650487869,"d":"2.43"},{"v":2.4655052751179114,"d":"2.47"},{"v":2.4719693563831133,"d":"2.47"},{"v":2.4733461115603195,"d":"2.47"},{"v":2.4737042484892573,"d":"2.47"},{"v":2.473814421508791,"d":"2.47"},{"v":2.4738519778841,"d":"2.47"},{"v":2.4738654474062347,"d":"2.47"},{"v":2.4738703877120494,"d":"2.47"},{"v":2.4738722167601437,"d":"2.47"},{"v":2.473872896524329,"d":"2.47"},{"v":2.473873149549125,"d":"2.47"},{"v":2.473873243789724,"d":"2.47"},{"v":2.4738732788989632,"d":"2.47"},{"v":2.4738732919801816,"d":"2.47"},{"v":2.47387329685426,"d":"2.47"},{"v":2.4738732986703758,"d":"2.47"},{"v":2.473873299347078,"d":"2.47"},{"v":2.4738732995992234,"d":"2.47"}]
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["%SHBG-C",null,{"v":0.06977393607711796,"d":"6.98E-02"},{"v":0.06904093620141669,"d":"6.90E-02"},{"v":0.07217911939577122,"d":"7.22E-02"},{"v":0.07404465667077183,"d":"7.40E-02"},{"v":0.07485885042054713,"d":"7.49E-02"},{"v":0.07518107707980917,"d":"7.52E-02"},{"v":0.07530403266439885,"d":"7.53E-02"},{"v":0.07535028474042846,"d":"7.54E-02"},{"v":0.0753675846099596,"d":"7.54E-02"},{"v":0.0753740406119616,"d":"7.54E-02"},{"v":0.07537644766971816,"d":"7.54E-02"},{"v":0.07537734478752774,"d":"7.54E-02"},{"v":0.07537767909666221,"d":"7.54E-02"},{"v":0.07537780366889463,"d":"7.54E-02"},{"v":0.07537785008662737,"d":"7.54E-02"},{"v":0.07537786738249935,"d":"7.54E-02"},{"v":0.0753778738271495,"d":"7.54E-02"},{"v":0.07537787622850005,"d":"7.54E-02"},{"v":0.07537787712327032,"d":"7.54E-02"},{"v":0.07537787745667165,"d":"7.54E-02"}]
["FSHBG_new (nmol/L)",{"v":30,"d":"30.000"},{"v":21.23540456203805,"d":"21.235"},{"v":20.022232631864505,"d":"20.022"},{"v":19.80844682383595,"d":"19.808"},{"v":19.763122709991187,"d":"19.763"},{"v":19.751357773581056,"d":"19.751"},{"v":19.747742896361835,"d":"19.748"},{"v":19.746511378004605,"d":"19.747"},{"v":19.74606981486149,"d":"19.746"},{"v":19.745907878080025,"d":"19.746"},{"v":19.745847927027555,"d":"19.746"},{"v":19.745825646682633,"d":"19.746"},{"v":19.745817353457,"d":"19.746"},{"v":19.745814264604626,"d":"19.746"},{"v":19.74581311385721,"d":"19.746"},{"v":19.74581268510476,"d":"19.746"},{"v":19.745812525351134,"d":"19.746"},{"v":19.745812465825797,"d":"19.746"},{"v":19.745812443646095,"d":"19.746"},{"v":19.745812435381705,"d":"19.746"},{"v":19.745812432302305,"d":"19.746"}]
["FALB_new (g/dL)",{"v":4.5,"d":"4.50E+00"},{"v":4.499834403085267,"d":"4.50E+00"},{"v":4.499781201249776,"d":"4.50E+00"},{"v":4.499763455526764,"d":"4.50E+00"},{"v":4.499757186395276,"d":"4.50E+00"},{"v":4.499754903492204,"d":"4.50E+00"},{"v":4.4997540609469615,"d":"4.50E+00"},{"v":4.499753748233281,"d":"4.50E+00"},{"v":4.499753631898595,"d":"4.50E+00"},{"v":4.499753588579078,"d":"4.50E+00"},{"v":4.499753572441979,"d":"4.50E+00"},{"v":4.499753566429754,"d":"4.50E+00"},{"v":4.499753564189627,"d":"4.50E+00"},{"v":4.499753563354948,"d":"4.50E+00"},{"v":4.499753563043937,"d":"4.50E+00"},{"v":4.499753562928054,"d":"4.50E+00"},{"v":4.499753562884872,"d":"4.50E+00"},{"v":4.499753562868783,"d":"4.50E+00"},{"v":4.499753562862788,"d":"4.50E+00"},{"v":4.499753562860555,"d":"4.50E+00"},{"v":4.499753562859722,"d":"4.50E+00"}]
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[]
["Model Convergence"]
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["% Change_FE2",null,null,{"v":-10.547394171869756,"d":"-1.05E+01"},{"v":-1.4824358120977994,"d":"-1.48E+00"},{"v":-0.2621807923283802,"d":"-2.62E-01"},{"v":-0.05569467006746283,"d":"-5.57E-02"},{"v":-0.01447985493270579,"d":"-1.45E-02"},{"v":-0.004453766839772723,"d":"-4.45E-03"},{"v":-0.0015181565352289596,"d":"-1.52E-03"},{"v":-0.0005444756701316895,"d":"-5.44E-04"},{"v":-0.00019969985918031951,"d":"-2.00E-04"},{"v":-7.393467754380025e-05,"d":"-7.39E-05"},{"v":-2.7477740403723556e-05,"d":"-2.75E-05"},{"v":-1.0227881785974334e-05,"d":"-1.02E-05"},{"v":-3.80943539514707e-06,"d":"-3.81E-06"},{"v":-1.4192012169250363e-06,"d":"-1.42E-06"},{"v":-5.287747946246116e-07,"d":"-5.29E-07"},{"v":-1.9702214272043568e-07,"d":"-1.97E-07"},{"v":-7.341184605575038e-08,"d":"-7.34E-08"},{"v":-2.7353946057110006e-08,"d":"-2.74E-08"},{"v":-1.0192345851437261e-08,"d":"-1.02E-08"}]
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["% Change_FDHT",null,null,{"v":-23.7124319517298,"d":"-2.37E+01"},{"v":-3.4093787351156775,"d":"-3.41E+00"},{"v":-0.6097324520893169,"d":"-6.10E-01"},{"v":-0.13108056651905947,"d":"-1.31E-01"},{"v":-0.03447115233668861,"d":"-3.45E-02"},{"v":-0.010686617960509296,"d":"-1.07E-02"},{"v":-0.003657998432709994,"d":"-3.66E-03"},{"v":-0.0013144170821784394,"d":"-1.31E-03"},{"v":-0.00048248497602507693,"d":"-4.82E-04"},{"v":-0.00017868933160301406,"d":"-1.79E-04"},{"v":-6.641864221879046e-05,"d":"-6.64E-05"},{"v":-2.472397270281552e-05,"d":"-2.47E-05"},{"v":-9.208791573147654e-06,"d":"-9.21E-06"},{"v":-3.4307557364032586e-06,"d":"-3.43E-06"},{"v":-1.278256820501822e-06,"d":"-1.28E-06"},{"v":-4.762806430616106e-07,"d":"-4.76E-07"},{"v":-1.7746564444962347e-07,"d":"-1.77E-07"},{"v":-6.612540029809378e-08,"d":"-6.61E-08"},{"v":-2.4638991884816176e-08,"d":"-2.46E-08"}]
["% Change_BDHT",null,null,{"v":-23.707986513993998,"d":"-2.37E+01"},{"v":-3.408184881449993,"d":"-3.41E+00"},{"v":-0.6093450131573696,"d":"-6.09E-01"},{"v":-0.13094434443497832,"d":"-1.31E-01"},{"v":-0.0344215948831211,"d":"-3.44E-02"},{"v":-0.010668332256566647,"d":"-1.07E-02"},{"v":-0.0036512121039903567,"d":"-3.65E-03"},{"v":-0.0013118925141430058,"d":"-1.31E-03"},{"v":-0.0004815449110673434,"d":"-4.82E-04"},{"v":-0.00017833914589544803,"d":"-1.78E-04"},{"v":-6.628817309664696e-05,"d":"-6.63E-05"},{"v":-2.4675360543096406e-05,"d":"-2.47E-05"},{"v":-9.190678530264458e-06,"d":"-9.19E-06"},{"v":-3.4240066156257343e-06,"d":"-3.42E-06"},{"v":-1.2757420604622572e-06,"d":"-1.28E-06"},{"v":-4.753435667761745e-07,"d":"-4.75E-07"},{"v":-1.771165151300882e-07,"d":"-1.77E-07"},{"v":-6.599530410613648e-08,"d":"-6.60E-08"},{"v":-2.459053338387098e-08,"d":"-2.46E-08"}]
["% Change_FCBG",null,{"v":30.417680921036727,"d":"3.04E+01"},{"v":10.783731719368928,"d":"1.08E+01"},{"v":3.95610720108723,"d":"3.96E+00"},{"v":1.4661767032626958,"d":"1.47E+00"},{"v":0.5452543154712864,"d":"5.45E-01"},{"v":0.20302332761523964,"d":"2.03E-01"},{"v":0.07562890647457689,"d":"7.56E-02"},{"v":0.028177439586584706,"d":"2.82E-02"},{"v":0.010498850689565544,"d":"1.05E-02"},{"v":0.003911936484775464,"d":"3.91E-03"},{"v":0.0014576238080187167,"d":"1.46E-03"},{"v":0.0005431258205978955,"d":"5.43E-04"},{"v":0.000202374570834165,"d":"2.02E-04"},{"v":7.540699146044985e-05,"d":"7.54E-05"},{"v":2.8097478960029056e-05,"d":"2.81E-05"},{"v":1.0469431979692505e-05,"d":"1.05E-05"},{"v":3.901026437230698e-06,"d":"3.90E-06"},{"v":1.453565718181336e-06,"d":"1.45E-06"},{"v":5.416146822563191e-07,"d":"5.42E-07"},{"v":2.0181165321592733e-07,"d":"2.02E-07"}]
["% Change_FC",null,null,{"v":-39.78937534749685,"d":"-3.98E+01"},{"v":-10.879930158623056,"d":"-1.09E+01"},{"v":-3.6917546419177403,"d":"-3.69E+00"},{"v":-1.3314568378112135,"d":"-1.33E+00"},{"v":-0.49026724107774483,"d":"-4.90E-01"},{"v":-0.1818811258566331,"d":"-1.82E-01"},{"v":-0.06766091858790631,"d":"-6.77E-02"},{"v":-0.025195983483070117,"d":"-2.52E-02"},{"v":-0.00938619275308369,"d":"-9.39E-03"},{"v":-0.003497106931488905,"d":"-3.50E-03"},{"v":-0.0013030202551600294,"d":"-1.30E-03"},{"v":-0.0004855141731584668,"d":"-4.86E-04"},{"v":-0.00018090718606292685,"d":"-1.81E-04"},{"v":-6.740791601380734e-05,"d":"-6.74E-05"},{"v":-2.5116922221925658e-05,"d":"-2.51E-05"},{"v":-9.35884175111475e-06,"d":"-9.36E-06"},{"v":-3.487207960279135e-06,"d":"-3.49E-06"},{"v":-1.2993723478812359e-06,"d":"-1.30E-06"},{"v":-4.841605208793188e-07,"d":"-4.84E-07"}]
[]
["Absolute Values"]
["Abs(% Change_FSHBG)",null,{"v":29.215318126539838,"d":"2.92E+01"},{"v":5.712968296079928,"d":"5.71E+00"},{"v":1.0677421042862285,"d":"1.07E+00"},{"v":0.22881205299864416,"d":"2.29E-01"},{"v":0.059529744275601607,"d":"5.95E-02"},{"v":0.018301917572754293,"d":"1.83E-02"},{"v":0.00623624868772559,"d":"6.24E-03"},{"v":0.0022361577428220993,"d":"2.24E-03"},{"v":0.000820096267164462,"d":"8.20E-04"},{"v":0.0003036125400815822,"d":"3.04E-04"},{"v":0.00011283559462348183,"d":"1.13E-04"},{"v":4.19998929481644e-05,"d":"4.20E-05"},{"v":1.5643071738113414e-05,"d":"1.56E-05"},{"v":5.8278043141627384e-06,"d":"5.83E-06"},{"v":2.17135879874791e-06,"d":"2.17E-06"},{"v":8.090506477857821e-07,"d":"8.09E-07"},{"v":3.0145803051414434e-07,"d":"3.01E-07"},{"v":1.123261029104886e-07,"d":"1.12E-07"},{"v":4.185388717112513e-08,"d":"4.19E-08"},{"v":1.5595204584799846e-08,"d":"1.56E-08"}]
["Abs(% Change_FALB)",null,{"v":0.0036799314385049797,"d":"3.68E-03"},{"v":0.0011823065189769779,"d":"1.18E-03"},{"v":0.0003943685752520812,"d":"3.94E-04"},{"v":0.00013932135654848337,"d":"1.39E-04"},{"v":5.073391690594667e-05,"d":"5.07E-05"},{"v":1.872424744310628e-05,"d":"1.87E-05"},{"v":6.949572720917301e-06,"d":"6.95E-06"},{"v":2.585356719359211e-06,"d":"2.59E-06"},{"v":9.627086371006703e-07,"d":"9.63E-07"},{"v":3.5862183230014924e-07,"d":"3.59E-07"},{"v":1.3361232537336914e-07,"d":"1.34E-07"},{"v":4.9783330615366024e-08,"d":"4.98E-08"},{"v":1.854943788993493e-08,"d":"1.85E-08"},{"v":6.911729016094136e-09,"d":"6.91E-09"},{"v":2.5753255446092287e-09,"d":"2.58E-09"},{"v":9.596405181994433e-10,"d":"9.60E-10"},{"v":3.5756073856081574e-10,"d":"3.58E-10"},{"v":1.33234059359323e-10,"d":"1.33E-10"},{"v":4.9622285219227296e-11,"d":"4.96E-11"},{"v":1.8514599656188665e-11,"d":"1.85E-11"}]
["Abs(% Change_FT)",null,null,{"v":20.043000171309682,"d":"2.00E+01"},{"v":3.0312064108572754,"d":"3.03E+00"},{"v":0.5971692750420683,"d":"5.97E-01"},{"v":0.14546809730013366,"d":"1.45E-01"},{"v":0.04271407111851595,"d":"4.27E-02"},{"v":0.014194057092465205,"d":"1.42E-02"},{"v":0.005030791697616156,"d":"5.03E-03"},{"v":0.0018358729187483277,"d":"1.84E-03"},{"v":0.00067828180340111,"d":"6.78E-04"},{"v":0.00025187044124296145,"d":"2.52E-04"},{"v":9.372052706946765e-05,"d":"9.37E-05"},{"v":3.490202548311079e-05,"d":"3.49E-05"},{"v":1.300200602733067e-05,"d":"1.30E-05"},{"v":4.844263095641987e-06,"d":"4.84E-06"},{"v":1.8049623257231272e-06,"d":"1.80E-06"},{"v":6.725394886635106e-07,"d":"6.73E-07"},{"v":2.50594262699588e-07,"d":"2.51E-07"},{"v":9.337398183586135e-08,"d":"9.34E-08"},{"v":3.479214700112515e-08,"d":"3.48E-08"}]
["Abs(% Change_FE2)",null,null,{"v":10.547394171869756,"d":"1.05E+01"},{"v":1.4824358120977994,"d":"1.48E+00"},{"v":0.2621807923283802,"d":"2.62E-01"},{"v":0.05569467006746283,"d":"5.57E-02"},{"v":0.01447985493270579,"d":"1.45E-02"},{"v":0.004453766839772723,"d":"4.45E-03"},{"v":0.0015181565352289596,"d":"1.52E-03"},{"v":0.0005444756701316895,"d":"5.44E-04"},{"v":0.00019969985918031951,"d":"2.00E-04"},{"v":7.393467754380025e-05,"d":"7.39E-05"},{"v":2.7477740403723556e-05,"d":"2.75E-05"},{"v":1.0227881785974334e-05,"d":"1.02E-05"},{"v":3.80943539514707e-06,"d":"3.81E-06"},{"v":1.4192012169250363e-06,"d":"1.42E-06"},{"v":5.287747946246116e-07,"d":"5.29E-07"},{"v":1.9702214272043568e-07,"d":"1.97E-07"},{"v":7.341184605575038e-08,"d":"7.34E-08"},{"v":2.7353946057110006e-08,"d":"2.74E-08"},{"v":1.0192345851437261e-08,"d":"1.02E-08"}]
["Abs(% Change_FE1)",null,null,{"v":3.108076001386267,"d":"3.11E+00"},{"v":0.4327201926193087,"d":"4.33E-01"},{"v":0.07649472438686779,"d":"7.65E-02"},{"v":0.016274847585040945,"d":"1.63E-02"},{"v":0.00423903839388944,"d":"4.24E-03"},{"v":0.001305585740532072,"d":"1.31E-03"},{"v":0.00044535169043415275,"d":"4.45E-04"},{"v":0.00015977410671872167,"d":"1.60E-04"},{"v":5.8609190563180023e-05,"d":"5.86E-05"},{"v":2.1700054147479285e-05,"d":"2.17E-05"},{"v":8.06498649041409e-06,"d":"8.06E-06"},{"v":3.002011486508257e-06,"d":"3.00E-06"},{"v":1.1181211269579446e-06,"d":"1.12E-06"},{"v":4.1655554531955245e-07,"d":"4.17E-07"},{"v":1.5520289356439608e-07,"d":"1.55E-07"},{"v":5.782883553575298e-08,"d":"5.78E-08"},{"v":2.15474346593407e-08,"d":"2.15E-08"},{"v":8.02879152404184e-09,"d":"8.03E-09"},{"v":2.991590371003577e-09,"d":"2.99E-09"}]
["Abs(% Change_FDHT)",null,null,{"v":23.7124319517298,"d":"2.37E+01"},{"v":3.4093787351156775,"d":"3.41E+00"},{"v":0.6097324520893169,"d":"6.10E-01"},{"v":0.13108056651905947,"d":"1.31E-01"},{"v":0.03447115233668861,"d":"3.45E-02"},{"v":0.010686617960509296,"d":"1.07E-02"},{"v":0.003657998432709994,"d":"3.66E-03"},{"v":0.0013144170821784394,"d":"1.31E-03"},{"v":0.00048248497602507693,"d":"4.82E-04"},{"v":0.00017868933160301406,"d":"1.79E-04"},{"v":6.641864221879046e-05,"d":"6.64E-05"},{"v":2.472397270281552e-05,"d":"2.47E-05"},{"v":9.208791573147654e-06,"d":"9.21E-06"},{"v":3.4307557364032586e-06,"d":"3.43E-06"},{"v":1.278256820501822e-06,"d":"1.28E-06"},{"v":4.762806430616106e-07,"d":"4.76E-07"},{"v":1.7746564444962347e-07,"d":"1.77E-07"},{"v":6.612540029809378e-08,"d":"6.61E-08"},{"v":2.4638991884816176e-08,"d":"2.46E-08"}]
["Abs(% Change_FCBG)",null,{"v":30.417680921036727,"d":"3.04E+01"},{"v":10.783731719368928,"d":"1.08E+01"},{"v":3.95610720108723,"d":"3.96E+00"},{"v":1.4661767032626958,"d":"1.47E+00"},{"v":0.5452543154712864,"d":"5.45E-01"},{"v":0.20302332761523964,"d":"2.03E-01"},{"v":0.07562890647457689,"d":"7.56E-02"},{"v":0.028177439586584706,"d":"2.82E-02"},{"v":0.010498850689565544,"d":"1.05E-02"},{"v":0.003911936484775464,"d":"3.91E-03"},{"v":0.0014576238080187167,"d":"1.46E-03"},{"v":0.0005431258205978955,"d":"5.43E-04"},{"v":0.000202374570834165,"d":"2.02E-04"},{"v":7.540699146044985e-05,"d":"7.54E-05"},{"v":2.8097478960029056e-05,"d":"2.81E-05"},{"v":1.0469431979692505e-05,"d":"1.05E-05"},{"v":3.901026437230698e-06,"d":"3.90E-06"},{"v":1.453565718181336e-06,"d":"1.45E-06"},{"v":5.416146822563191e-07,"d":"5.42E-07"},{"v":2.0181165321592733e-07,"d":"2.02E-07"}]
["Abs(% Change_FC)",null,null,{"v":39.78937534749685,"d":"3.98E+01"},{"v":10.879930158623056,"d":"1.09E+01"},{"v":3.6917546419177403,"d":"3.69E+00"},{"v":1.3314568378112135,"d":"1.33E+00"},{"v":0.49026724107774483,"d":"4.90E-01"},{"v":0.1818811258566331,"d":"1.82E-01"},{"v":0.06766091858790631,"d":"6.77E-02"},{"v":0.025195983483070117,"d":"2.52E-02"},{"v":0.00938619275308369,"d":"9.39E-03"},{"v":0.003497106931488905,"d":"3.50E-03"},{"v":0.0013030202551600294,"d":"1.30E-03"},{"v":0.0004855141731584668,"d":"4.86E-04"},{"v":0.00018090718606292685,"d":"1.81E-04"},{"v":6.740791601380734e-05,"d":"6.74E-05"},{"v":2.5116922221925658e-05,"d":"2.51E-05"},{"v":9.35884175111475e-06,"d":"9.36E-06"},{"v":3.487207960279135e-06,"d":"3.49E-06"},{"v":1.2993723478812359e-06,"d":"1.30E-06"},{"v":4.841605208793188e-07,"d":"4.84E-07"}]

{"sheet":"KSHBG-X","index":2,"n_rows":16,"n_cols":10,"rows_kept":16,"merged":[[0,0,0,9],[1,2,1,3],[1,4,1,5],[1,6,1,7],[1,8,1,9]],"flags":["formulas_cached_only"]}
["Table 1. Association Constants Between SHBG and Steroids at 37 oC (L/mol); Normalized by Testosterone"]
["Reference","T","DHT",null,"E2",null,"E1",null,"C"]
[null,"L/mol","L/mol","Normalized","L/mol","Normalized","L/mol","Normalized","L/mol","Normalized"]
["Vermeulen 1973",{"v":800000000,"d":"8.00E+08"}]
["Anderson 1974",{"v":1660000000,"d":"1.66E+09"},null,null,{"v":640000000,"d":"6.40E+08"},{"v":0.3855421686746988,"d":"0.39"}]
["Rosner & Smith 1975",{"v":350000000,"d":"3.50E+08"},{"v":990000000,"d":"9.90E+08"},{"v":2.8285714285714287,"d":"2.83"},{"v":220000000,"d":"2.20E+08"},{"v":0.6285714285714286,"d":"0.63"}]
["Dunn 1981",{"v":1600000000,"d":"1.60E+09"},{"v":5500000000,"d":"5.50E+09"},{"v":3.4375,"d":"3.44"},{"v":680000000,"d":"6.80E+08"},{"v":0.425,"d":"0.43"},{"v":150000000,"d":"1.50E+08"},{"v":0.09375,"d":"0.094"},{"v":1600000,"d":"1.60E+06"},0.001]
["Moll 1981",{"v":980000000,"d":"9.80E+08"},null,null,{"v":500000000,"d":"5.00E+08"},{"v":0.5102040816326531,"d":"0.51"}]
["Sodergard 1982",{"v":597000000,"d":"5.97E+08"},{"v":1070000000.0000001,"d":"1.07E+09"},{"v":1.7922948073701845,"d":"1.79"},{"v":314000000,"d":"3.14E+08"},{"v":0.525963149078727,"d":"0.53"}]
[]
["n",6,3,3,5,5,1,1,1,1]
["Mean",{"v":997833333.3333334,"d":"9.98E+08"},{"v":2520000000,"d":"2.52E+09"},{"v":2.686122078647205,"d":"2.69"},{"v":470800000,"d":"4.71E+08"},{"v":0.4950561655915015,"d":"0.50"},{"v":150000000,"d":"1.50E+08"},{"v":0.09375,"d":"0.094"},{"v":1600000,"d":"1.60E+06"},0.001]
["SD",{"v":533081763.58478683,"d":"5.33E+08"},{"v":2581065671.384593,"d":"2.58E+09"},{"v":0.8318015955950065,"d":"0.83"},{"v":200457476.7874723,"d":"2.00E+08"},{"v":0.09475258346787382,"d":"0.09"}]
["CV(%)",{"v":53.42392820291834,"d":"53.4"},{"v":102.42324092796004,"d":"102.4"},{"v":30.966634100782255,"d":"31.0"},{"v":42.57805369317594,"d":"42.6"},{"v":19.139764344650033,"d":"19.1"}]
[]
["Model Value",{"v":1000000000,"d":"1.00E+09"},{"v":2686122078.647205,"d":"2.69E+09"},null,{"v":495056165.59150153,"d":"4.95E+08"},null,{"v":93750000,"d":"9.38E+07"},null,{"v":1000000,"d":"1.00E+06"}]

{"sheet":"KAlb-X","index":3,"n_rows":16,"n_cols":10,"rows_kept":16,"merged":[[0,0,0,9],[1,2,1,3],[1,4,1,5],[1,6,1,7],[1,8,1,9]],"flags":["formulas_cached_only"]}
["Table 2. Association Constants Between Albumin and Steroids at 37 oC (L/mol); Normalized by Testosterone"]
["Reference","T","DHT",null,"E2",null,"E1",null,"C"]
[null,"L/mol","L/mol","Normalized","L/mol","Normalized","L/mol","Normalized","L/mol","Normalized"]
["Clark 1973",{"v":25300,"d":"2.53E+04"},{"v":42400,"d":"4.24E+04"},{"v":1.6758893280632412,"d":"1.68"}]
["Anderson 1974",{"v":36000,"d":"3.60E+04"},null,null,{"v":55500,"d":"5.55E+04"},{"v":1.5416666666666667,"d":"1.54"}]
["Vermeulen 1973",{"v":36000,"d":"3.60E+04"}]
["Dunn 1981",{"v":40000,"d":"4.00E+04"},{"v":80000,"d":"8.00E+04"},{"v":2,"d":"2.00"},{"v":60000,"d":"6.00E+04"},{"v":1.5,"d":"1.50"},{"v":40000,"d":"4.00E+04"},{"v":1,"d":"1.00"},{"v":3000,"d":"3.00E+03"},0.075]
["Moll 1981",{"v":36000,"d":"3.60E+04"},null,null,{"v":35000,"d":"3.50E+04"},{"v":0.9722222222222222,"d":"0.97"}]
["Sodergard 1982",{"v":40600,"d":"4.06E+04"},{"v":66100,"d":"6.61E+04"},{"v":1.6280788177339902,"d":"1.63"},{"v":42100,"d":"4.21E+04"},{"v":1.0369458128078817,"d":"1.04"}]
[]
["n",6,3,3,4,4,1,1,1,1]
["Mean",{"v":35650,"d":"3.57E+04"},{"v":62833.333333333336,"d":"6.28E+04"},{"v":1.7679893819324104,"d":"1.768"},{"v":48150,"d":"4.82E+04"},{"v":1.2627086754241927,"d":"1.263"},{"v":40000,"d":"4.00E+04"},{"v":1,"d":"1.000"},{"v":3000,"d":"3.00E+03"},0.075]
["SD",{"v":5493.905714516768,"d":"5.5E+03"},{"v":19011.66308699302,"d":"1.90E+04"},{"v":0.20234415335404313,"d":"0.202"},{"v":11604.165918611585,"d":"1.16E+04"},{"v":0.2997087381817822,"d":"0.300"}]
["CV(%)",{"v":15.410675216035814,"d":"15.4"},{"v":30.25728873261488,"d":"30.3"},{"v":11.444873788375427,"d":"11.4"},{"v":24.100033060460195,"d":"24.1"},{"v":23.73538283334423,"d":"23.7"}]
[]
["Model Value",{"v":36000,"d":"3.60E+04"},{"v":63647.61774956677,"d":"6.36E+04"},null,{"v":45457.51231527094,"d":"4.55E+04"},null,{"v":36000,"d":"3.60E+04"},null,{"v":2700,"d":"2.70E+03"}]

{"sheet":"KCBG-X","index":4,"n_rows":19,"n_cols":10,"rows_kept":19,"merged":[[0,0,0,9]],"flags":["formulas_cached_only"]}
["Table 3. Association Constants Between CBG and Steroid Hormones at 37 oC (L/mol); Normalization by Cortisol"]
["Reference","C","T",null,"DHT",null,"E2",null,"E1"]
[null,"L/mol","L/mol","Normalized","L/mol","Normalized","L/mol","Normalized","L/mol","Normalized"]
["Vermeulen 1971(T), 1973(C) ",{"v":30000000,"d":"3.00E+07"},{"v":1500000,"d":"1.50E+06"},{"v":0.05,"d":"5.00E-02"}]
["Dunn 1981",{"v":76000000,"d":"7.60E+07"},{"v":5300000,"d":"5.30E+06"},{"v":0.06973684210526315,"d":"6.97E-02"},{"v":830000,"d":"8.30E+05"},{"v":0.010921052631578948,"d":"1.09E-02"}]
["Mickelson 1981 a, b",{"v":40000000,"d":"4.00E+07"},{"v":2400000,"d":"2.40E+06"},{"v":0.06,"d":"6.00E-02"},null,null,{"v":4400,"d":"4.40E+03"},{"v":0.00011,"d":"1.10E-04"},{"v":378.4,"d":"3.78E+02"},{"v":9.46e-06,"d":"9.5E-06"}]
["Pugeat 1984",{"v":48000000,"d":"4.80E+07"}]
["Klosterman 1986",{"v":94000000,"d":"9.40E+07"}]
["Gayrard 1996",{"v":25600000,"d":"2.56E+07"}]
[]
["n",6,3,3,1,1,1,1,1,1]
["Mean",{"v":52266666.666666664,"d":"5.23E+07"},{"v":3066666.6666666665,"d":"3.07E+06"},{"v":0.05991228070175438,"d":"0.060"},{"v":830000,"d":"8.30E+05"},{"v":0.010921052631578948,"d":"0.011"},{"v":4400,"d":"4.40E+03"},{"v":0.00011,"d":"1.10E-04"},{"v":378.4,"d":"3.78E+02"},{"v":9.46e-06,"d":"9.46E-06"}]
["SD",{"v":27131285.754026968,"d":"2.71E+07"},{"v":1985782.8011475308,"d":"1.99E+06"},{"v":0.009868713445960749,"d":"0.010"}]
["CV(%)",{"v":51.90934774367405,"d":"51.9"},{"v":64.75378699394122,"d":"64.8"},{"v":16.4719375232727,"d":"16.5"}]
[]
["Model Value",{"v":52266666.666666664,"d":"5.23E+07"},{"v":3131415.2046783622,"d":"3.13E+06"},null,{"v":570807.0175438597,"d":"5.71E+05"},null,{"v":5749.333333333333,"d":"5.7E+03"},null,{"v":494.4426666666666,"d":"4.94E+02"}]
[]
["a Values for T and E2 are estimated from data obtained at 4 oC."]
["b Value for E1 is estimated from value for E2 based on the ratio of cortisone to cortisol binding affinities (Dunn 1981, Mickelson 1981)."]

{"sheet":"Vermeulen Calc","index":5,"n_rows":19,"n_cols":14,"rows_kept":19,"merged":[[9,7,9,13]],"flags":["formulas_cached_only"]}
["Calculation of Bioavailable T and Free T ",{"$nulls":6},"Note: columns E-G contain hidden cells for calculation"]
["Vermeulen FT BT Model"]
["JCEM 1999;84:3666-3672"]
[]
["Table of Constants (Vermeulen 1999)"]
["K SHBG (L/nmol)",1]
["K Alb (L/mol)",{"v":36000,"d":"3.60E+04"}]
["MW Alb (g/mol)",69000]
[]
[{"$nulls":4},"Derived Parameters",null,null,"Calculated Results"]
[null,"T (ng/dL)","Alb (g/dL)","SHBG (nmol/L)","K (L/nmol)","T (nmol/L)","b","BT (nmol/L)","BT (ng/dL)","FT(ng/dL)","FT (pg/mL)","FT (pmol/L)","%FT","%BT"]
[null,null,"Default 4.3 *"]
["ex. 1",120,3.7,335,{"v":0.04925053533190578,"d":"0.049"},{"v":4.160887656033287,"d":"4.16"},{"v":17.294003391672877,"d":"17.294"},{"v":0.24043250699321408,"d":"0.24"},{"v":6.934073501684294,"d":"6.93"},{"v":0.34150683198873394,"d":"0.34"},{"v":3.4150683198873395,"d":"3.42"},{"v":11.841429680607973,"d":"11.84"},{"v":0.2845890266572783,"d":"0.28"},{"v":5.778394584736912,"d":"5.78"}]
["ex. 2",350,4.3,55,{"v":0.04267161410018553,"d":"0.043"},{"v":12.135922330097088,"d":"12.14"},{"v":2.8290793810904766,"d":"2.829"},{"v":4.043141970224475,"d":"4.04"},{"v":116.60421442127387,"d":"116.60"},{"v":4.975690040239886,"d":"4.98"},{"v":49.75690040239886,"d":"49.76"},{"v":172.5273939056826,"d":"172.53"},{"v":1.4216257257828246,"d":"1.42"},{"v":33.315489834649675,"d":"33.32"}]
["Multi-Ligand Data",600,4.5,30,{"v":0.0408525754884547,"d":"0.041"},{"v":20.804438280166437,"d":"20.80"},{"v":1.375662379318245,"d":"1.376"},{"v":11.31869293274099,"d":"11.32"},{"v":326.43110418025014,"d":"326.43"},{"v":13.33555132530329,"d":"13.34"},{"v":133.3555132530329,"d":"133.36"},{"v":462.39775746544007,"d":"462.40"},{"v":2.2225918875505486,"d":"2.22"},{"v":54.40518403004169,"d":"54.41"}]
["input data:",{"$nulls":3},{"v":0.04267161410018553,"d":"0.043"},{"v":0,"d":"0.00"},{"v":1,"d":"1.000"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"$error":"#DIV/0!"},{"$error":"#DIV/0!"}]
[]
[]
["* If Alb is left empty, the default value will be 4.3 g/dL"]

{"sheet":"Steroids 2009","index":6,"n_rows":33,"n_cols":7,"rows_kept":33,"merged":[[0,0,0,6]],"flags":["formulas_cached_only"]}
["Table 4. Illustrative Examples of Calculated Free and Bioavailable Hormone Concentrations in Male and Female Populations Based on the Concentrations of Total Hormone and Binding Proteins."]
[null,"YM","OM","Ob M","YW","Preg T3","CEE"]
[]
["Input Data:"]
["T_tot (ng/dL)",600,350,300,34,120,21]
["DHT_tot (ng/dL)",50,35,20.3,12.4,18,7.6]
["E2_tot (pg/mL)",{"v":21.5,"d":"22"},19,48,130,18000,36]
["E1_tot (pg/mL)",30,28,57.6,95,16000,148]
["Cortisol (ug/dL)",13,11,13,13,30,13]
["Alb_tot (g/dL)",4.5,4.3,4.5,4.5,3.7,4.3]
["SHBG_tot (nmol/L)",30,55,18.1,60,335,210]
["CBG (mg/dL)",4,3.4,2.15,4.5,11.7,6.5]
[]
["Calculated Results:"]
["cFT (pg/mL)",{"v":131.50498042122652,"d":"131.50"},{"v":49.84780951260634,"d":"49.85"},{"v":77.83278961832787,"d":"77.83"},{"v":4.044943963827316,"d":"4.04"},{"v":4.491939466055913,"d":"4.49"},{"v":0.8990568993951423,"d":"0.90"}]
["cFDHT (pg/mL)",{"v":5.219074590875766,"d":"5.22"},{"v":2.1434177383511934,"d":"2.14"},{"v":2.565507373711286,"d":"2.57"},{"v":0.6252727718015636,"d":"0.63"},{"v":0.2620839978925539,"d":"0.26"},{"v":0.127093240953849,"d":"0.13"}]
["cFE2 (pg/mL)",{"v":0.5318827594138331,"d":"0.53"},{"v":0.3661629956610417,"d":"0.37"},{"v":1.2841859024184905,"d":"1.28"},{"v":2.1919923337908154,"d":"2.19"},{"v":123.85268712462539,"d":"123.85"},{"v":0.27282505865801665,"d":"0.27"}]
["cFE1(pg/mL)",{"v":1.1394554219890158,"d":"1.14"},{"v":1.0106029757788226,"d":"1.01"},{"v":2.2367964601236214,"d":"2.24"},{"v":3.176739059514323,"d":"3.18"},{"v":371.93038960280745,"d":"371.93"},{"v":3.4524523505973916,"d":"3.45"}]
["cFC (ng/mL)",{"v":4.9626340275615455,"d":"4.96"},{"v":4.799788878036386,"d":"4.80"},{"v":12.31311375545366,"d":"12.31"},{"v":4.192687682058001,"d":"4.19"},{"v":3.8212522726912574,"d":"3.82"},{"v":2.5717898540232484,"d":"2.57"}]
[]
["cBT (ng/dL)",{"v":321.8844132687252,"d":"321.88"},{"v":116.81248940318758,"d":"116.81"},{"v":190.5024020301107,"d":"190.50"},{"v":9.901009175652968,"d":"9.90"},{"v":9.119729420810165,"d":"9.12"},{"v":2.106880357331382,"d":"2.11"}]
["cBDHT (ng/dL)",{"v":22.184742656916942,"d":"22.18"},{"v":8.715729424344314,"d":"8.72"},{"v":10.904704786706844,"d":"10.90"},{"v":2.6579070080782503,"d":"2.66"},{"v":0.9206092055545341,"d":"0.92"},{"v":0.516807786198227,"d":"0.52"}]
["cBE2 (pg/mL)",{"v":16.299323848517552,"d":"16.30"},{"v":10.738603768533828,"d":"10.74"},{"v":39.351520392488496,"d":"39.35"},{"v":67.17412106039279,"d":"67.17"},{"v":3142.5573266649535,"d":"3142.56"},{"v":8.001422502990048,"d":"8.00"}]
["cBE1 (pg/mL)",{"v":27.890422003636928,"d":"27.89"},{"v":23.68229427797401,"d":"23.68"},{"v":54.747504309630706,"d":"54.75"},{"v":77.75861138789624,"d":"77.76"},{"v":7551.091331897058,"d":"7551.09"},{"v":80.90593650957867,"d":"80.91"}]
[]
["Vermeulen Model [12]:"]
["cFT (pg/mL)",{"v":133.3555132530329,"d":"133.36"},{"v":49.75690040239886,"d":"49.76"},{"v":77.42432110482143,"d":"77.42"},{"v":4.0648292702357125,"d":"4.06"},{"v":3.4150683198873395,"d":"3.42"},{"v":0.9021396177296669,"d":"0.90"}]
["% Difference",{"v":-1.3876687859879715,"d":"-1.4"},{"v":0.18270653813293794,"d":"0.2"},{"v":0.5275713208430035,"d":"0.5"},{"v":-0.4892039760194822,"d":"-0.5"},{"v":31.532931271023564,"d":"31.5"},{"v":-0.3417118895944906,"d":"-0.3"}]
[]
[null,"Kudielka 2004","Kenny 2001","Isidori  1999 (T, E2, SHBG)","Shifren 2000","Zhang 2005","Shifren 2000"]
[null,"Esoterix","Vermeulen 1996","Blanchette 2006 (DHT)","Fernandez 2005","Soldin 2005","Prip 2004 (CBG, C)"]
[null,null,"Kudielka 2004","Zumoff 2003 (E1)",null,"Mazer 2005"]
[{"$nulls":3},"Purnell 2008 (CBG, C)"]